SoftPac Citrate SelectBag Citrate

SoftPac Citrate and SelectBag Citrate Concentrates

SoftPac and SelectBag citrate concentrates are designed to meet dialysis patients' specialised needs 

Improved haemodynamic stability – Citrate-containing fluids may offer a greater haemodynamic stability with significantly fewer episodes of arterial hypotension.1

Improved control of acid-base balance – Dialysis with citrate achieves a better control of post-dialysis acid-base balance by decreasing / avoiding post-alkalemia compared to acetate.1

Decreased thrombogenicity – Citrate has a local anticoagulant effect inside the dialyser allowing reduced heparin dosing while maintaining extracorporeal patency2 and optimising dialyser clearances.3-5

Reduction of inflammatory indicators – Citrate concentrate has been shown to reduce inflammation markers such as pentraxin-3,3 CRP5 and IL6.4 In vitro studies show that citrate is a promising substitute for acetate for a more biocompatible dialysis, most likely resulting in less adverse effects for the patients.6

Citrate dialysis fluid

The Vantive SoftPac citrate and SelectBag citrate concentrates allow for acetate-free dialysis fluids, which may help to promote patient well-being with all the beneficial properties of citrate.*7

citrus fruits, orange, lemon and lime
SelectBag citrate concentrate

SelectBag citrate concentrate is an acetate-free concentrate with all the beneficial properties of citrate. With the BiCart Select citrate system, it is easy to optimise the dialysis fluid composition. Sodium and bicarbonate levels are accurately controlled to the provider's settings, while the SelectBag citrate concentrate allows providers to easily vary potassium, calcium and glucose.

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SoftPac citrate concentrate

SoftPac citrate concentrate is an acetate-free concentrate with all the beneficial properties of citrate. PVC-free SoftPac citrate concentrate is available in two sizes: a 3.5 L bag and a 5 L bag.

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Related products

*Compared to concentrate containing acetate

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Vantive, AK 98, Artis Physio Plus, BiCart Select, SelectBag and SoftPac are trademarks of Vantive Health LLC or its affiliates.

References

  1. de Sequera P, Garcia RP, Molina M, et al. Prospective randomized multicenter study to demonstrate the benefits of haemodialysis without acetate (with citrate): ABC-treat Study. Acute effect of citrate. Nefrologia. 2019;39(4):424-433.

  2. Meijers B, Metalidis C, Vanhove T, et al. A noninferiority trial comparing a heparin-grafted membrane plus citrate-containing dialysate versus regional citrate anticoagulation: results of the CiTED study. Nephrol Dial Transplant. 2017;32:707-714.

  3. Grundstrom G, Christensson A, Alquist M, et al. Replacement of acetate with citrate in dialysis fluid: a randomized clinical trial of short term safety and fluid biocompatibility. BMC Nephrol. 2013,14:216.

  4. Dellepiane S, Medica D, Guarena C, et al. Citrate anion improves chronic dialysis efficacy, reduces systemic inflammation and prevents chemerin-mediated microvascular injury. Sci Rep. 2019;9:10622.

  5. Molina Nunez M, de Alarcon R, Roca S, et al. Citrate versus acetate-based dialysate in on-line haemodiafiltration. A prospective cross-over study. Blood Purif. 2015;39:181-187.

  6. Huang S, Sandholm K, Jonsson N, et al. Low concentrations of citrate reduce complement and granulocyte activation in vitro in human blood. Clin Kidney J. 2015;8:31-37.

  7. Bryland A, Wieslander A, Carlsson O, et al. Citrate treatment reduces endothelial death and inflammation under hyperglycaemic conditions. Diab Vasc Dis Res. 2012;9(1):42-51.