TPE filtration set

TPE Filtersets

Therapeutic plasma exchange is associated with positive clinical outcomes1

Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique used to treat patients with a variety of disorders; it has become a relatively common treatment modality. It is associated with positive clinical outcomes in the treatment of Guillain-Barré syndrome, thrombotic thrombocytopenic purpura (TTP), myasthenia gravis and Goodpasture syndrome.

Compatible Products

Acute Therapy Systems
CRRT Solutions
Filtersets & Catheters
Digital Solutions

Expand beyond CRRT to deliver membrane therapeutic plasma exchange in the ICU

Treatment indications for TPE have increased over time. TPE can be delivered in the ICU using Vantive’s PrisMax and Prismaflex systems, giving clinicians the flexibility to deliver multiple therapies at the bedside anytime, with ease and confidence, in a simple and efficient manner.

Hospitals that already own a PrisMax or Prismaflex device can run TPE without purchasing a new device.2

Healthcare professional interacts with the PrisMax system with a TPE filterset attached to it

Gain control and flexibility with PrisMax and Prismaflex to deliver multiple therapies at the bedside

Simplicity

Designed for improved ease of use for TPE delivery to enable more time for patient care.

Confidence

Provides enhanced safety features for greater confidence in the delivery of TPE therapy.

Efficiency

Helps to streamline operations in the ICU when delivering TPE therapy.

TPE filtersets powered by PrisMax and Prismaflex expand treatment options in the ICU

Simplicity and improved ease of use for TPE delivery

Setting up and delivering TPE therapy on the PrisMax and Prismaflex systems is similar to setting up a CRRT procedure,2 which may reduce the amount of additional training required.   

The intuitive user interface of the PrisMax and Prismaflex systems may help to support smooth therapy initiation.2,3

The systems offer the capability for citrate anticoagulation and an integrated syringe pump for heparin anticoagulation.2

Enhanced safety features for greater confidence

The PrisMax and Prismaflex systems offer the ability to delay the start of therapy until the TPE circuit has been filled with blood before initiating treatment.2

The self-regulating pressure system can automatically accommodate blood flow rate adjustments.2

Flow-rate capabilities allow adjustments for lower-body-weight patients.2

Efficiencies to help streamline operations in the ICU

The only additional incremental cost includes the purchase of TPE filtersets, anticoagulant, replacement solution and procedural disposables,2 allowing for an affordable and predictable treatment cost.4

Around-the-clock critical care support

TPE with the PrisMax System or the Prismaflex System allows clinicians to autonomously support time-critical indications with TPE therapy, 24/7. This can help meet diverse patient needs and the demands of multiple critical care therapies in the ICU.

Vantive offers different TPE filtersets for plasma protein removal to meet individual patient needs

 

TPE 2000 set

TPE 1000 set

Minimal Patient Weight

Adult*

9 kg

Effective Surface Area

0.35 m2

0.15 m2

Blood Priming Volume

41 mL ± 10%

23 mL ± 10%

Blood Volume in Set

 

125 mL ± 10%

71 mL ± 10%

Minimum Blood Flow Rate

100 mL/min

50 mL/min

Maximum Blood Flow Rate

400 mL/min

180 mL/min

Plasmafilter Hollow Fiber

Polypropylene

Polypropylene

Related products

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*The size, weight, state of uremia, cardiac status and general physical condition of the patient must be evaluated by the prescribing physician before each treatment.5

 

Vantive, Prismaflex and PrisMax are trademarks of Vantive Health LLC or its affiliates.

References

  1. Padmanabhan A, Connelly‐Smith L, Aqui N, et al. Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the Writing Committee of the American Society for Apheresis: the eighth special issue. J Clin Apher. 2019;34:171-354.  

  2. Vantive Health LLC. PrisMax Operator’s Manual AW8061. 2022.

  3. Broman M, Bell M, Joannes-Boyau O, Ronco C. The novel PrisMax Continuous Renal Replacement Therapy system in a multinational,multicentre pilot setting. Blood Purif. 2018;46:220–227.

  4. Kaplan AA. Why nephrologists should perform therapeutic plasma exchange. Dial and Transplant. 2009;38:65–70.

  5. TPE 1000/2000 IFU. 2020